opac, catalogo, online,servizi, biblioteca, sebina

Proteomic profiling of EGF-induced ubiquitinated proteins : phd degree in molecular medicine : tesi di dottorato

Argenzio, Elisabetta <1976- >

Tesi o dissertazioni - 2008

Protein post-translational modifications (PTMs) are major players in regulating a broad range of cellular processes. Among these, ubiquitination, i.e. the covalent attachment of one or more ubiquitin (Ub) to a lysine of the substrate, is involved in the regulation of several events, such as cell division, differentiation, signal transduction and protein trafficking. Because of the large numbers of Ub moieties that can be conjugated to a single substrate and the widespread number of proteins that can be involved in the reaction, large scale identification of modified proteins can be helpful in understanding how Ub works in intracellular pathways. Proteomics technologies for global detection and quantitation of proteins are election tools to gain insights into PTMs-mediated network and have already been used for the characterizations of Ub-conjugated proteome in human and yeast cells. Despite this bulk of informations, little is known about the inducibility of the process and the pathways to which modified proteins belong [...]
  • Lo trovi in
  • Scheda
  • Unimarc