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Modificazione dell'assetto epigenetico di cellule della granulosa umana con 5-azacitidina e loro differenziamento in cellule muscolari scheletriche : dottorato di ricerca in biotecnologie applicate alle scienze veterinarie e zootecniche : tesi di dottorato

Antonini, Stefania <1980- >

Tesi o dissertazioni - 2009

Abstract
MODIFICAZIONE DELL’ASSETTO EPIGENETICO DI CELLULE DELLA GRANULOSA UMANA CON 5-AZACITIDINA E LORO DIFFERENZIAMENTO IN CELLULE MUSCOLARI SCHELETRICHE Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type. Through this method it becomes possible to derive one kind of specialized cell from another more accessible tissue in the same individual. Early studies in frog cloning provided some of the first experimental evidence for reprogramming; subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion and induction of pluripotency by ectopic gene expression. All these techniques present both practical and ethical problems, so the aim of the present study is to develop an alternative technique in order to improve or substitute the other procedures. In particular, we reprogramme primary culture of human granulose cells using 5-Azacytidine, a chemical that induce DNA demethylation increasing the differentiation plasticity of the cell [...]
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Archivio Tesi di dottorato

Documento per sola consultazione interna

Inventario
3830
Collocazione
D. 2009 0067
Note
Documento consultabile previa autorizzazione.