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Mechanisms of estrogen receptor mediated transcriptional repression in breastcancer cells : dottorato di ricerca in scienze endocrinologiche e metaboliche : tesi di dottorato

Stossi, Fabio <1975- >

Tesi o dissertazioni - 2008

Abstract
Mechanisms of Estrogen Receptor Mediated Transcriptional Repression in Breast Cancer Cells. Fabio Stossi, numero di matricola: R06770 Tesi di Dottorato di Ricerca in Scienze Endocrinologiche e Metaboliche (XXI Ciclo) The regulation of gene expression by nuclear receptors controls the phenotypic properties and diverse biologies of target cells. In breast cancer cells, estrogen receptor alpha is a master regulator of transcriptional stimulation and repression, yet the mechanisms by which agonist bound ER? elicits repression are poorly understood. We analyzed selected early estrogen-repressed genes and found that ER? is recruited to ER? binding sites of these genes, albeit more transiently and less efficiently than for estrogen-stimulated genes. Of multiple coregulators studied (coactivators and corepressors), only p300 was recruited to ER? binding sites of repressed genes, and its knockdown prevented estrogen-mediated gene repression. Because p300 is involved in transcription initiation, [...]
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