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Cross-talk epitelio-matrice nell'immunita innata a livello cutaneo : dottorato di ricerca in scienze morfologiche : tesi di dottorato

Gariboldi, Silvia <1978- >

Tesi o dissertazioni - 2009

Abstract
Skin and hair follicle are constantly in contact with different pathogens, which are present in the environment. In the first phase of our research project we aimed to analyse the expression pattern of four different members of the toll-like receptor (TLR) family in murine skin and hair follicle and to evaluate the effect of their activation by their specific microbial agonists, in terms of production of the antimicrobial peptide beta-defensin 2 (DEFB2). TLR and DEFB2 protein expression was investigated on murine skin samples. Murine hair follicle expresses TLR2, TLR4 and TLR5; agonists of TLR2, TLR4 and TLR5 but not of TLR9 induced DEFB2 production in this compartment. Our data show that the hair follicle is equipped with TLR2, TLR4 and TLR5, and that these receptors are able to respond to microbial stimuli inducing DEFB2 production. This immune response might be important in preserving the skin from microorganism infections. In the second phase of our project we aimed to investigate on [...]
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