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Metodi computazionali in neuroimaging : dottorato di ricerca in matematica e statistica per le scienze computazionali : tesi di dottorato

Giuliani, Donatella <1958- >

Tesi o dissertazioni - 2009

Abstract By applying magnetic field gradients, MR imaging may be able to register molecular diffusion,the spontaneus random motion of water molecules of brain. Diffusion is strongly anisotropic in WM fiber tracts, because axonal membranes and myelin sheaths represent barriers to the water molecular motion, in directions not parallel to their ones. There in diffusion anisotropy is a marker for WM tracts integrity. A common measure of diffusion motion is the fractional anisotropy FA (Basser et al. 1996), a scalar voxelwise quantity useful to compare across subjects. In our study we have analyzed a dataset composed by a group of 17 patients affected by Alzheimer diseases and a control group of 11 unities. After have been realized FA images for each subject, we have used the Tract Based Spatial Statistical method (Smith et al.,2006) for a voxelwise statistical analysis.The TBSS is a fully automated approach, investigating the whole brain with a great limitations of problems caused by alignment [...]
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D. 2009 0288
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